Neuropeptide S: A Neuropeptide Promoting Arousal and Anxiolytic-like Effects
✍ Scribed by Yan-Ling Xu; Rainer K Reinscheid; Salvador Huitron-Resendiz; Stewart D Clark; Zhiwei Wang; Steven H Lin; Fernando A Brucher; Joanne Zeng; Nga K Ly; Steven J Henriksen; Luis de Lecea; Olivier Civelli
- Book ID
- 116782023
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 851 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0896-6273
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📜 SIMILAR VOLUMES
Effects of intracerebroventircular (ICV), neuropeptide Y (NPY) (0.2-5.0 nmol) and its C-terminal 13-36 amino acid (AA) fragment (0.4~2.0 nmol) have been examined with respect to anxiolytic properties in two rat anxiety models, Montgomery's conflict test (MT), and Vogel's drinking conflict test (VT).
## Abstract Neuropeptide Y (NPY) exerts anxiolytic‐ and antidepressant‐like effects in rodents that appear to be mediated via Y1 receptors. Gene therapy using recombinant viral vectors to induce overexpression of NPY in the hippocampus or amygdala has previously been shown to confer anxiolytic‐like