Neuropeptide families: An evolutionary perspective

✍ Scribed by Sherwood, Nancy M. ;Parker, David B.

• Publisher: John Wiley and Sons
• Year: 1990
• Tongue: English
• Weight: 861 KB
• Volume: 256
• Category: Article
• ISSN: 0022-104X
• DOI: 10.1002/jez.1402560412

✦ Synopsis

Changes in the structure and function of five neuropeptide families during evolution are considered. The families of gonadotropin-releasing hormone (GnRH), corticotropin-releasing factor (CRF), growth hormone-releasing hormone (GH-RH), somatostatin (SS), and vasopressin/oxytocin (VP/Oxy) are used as models to illustrate the importance of a phylogenetic approach in understanding neuropeptide structure/activity relationships, precursors, processing, gene duplication, novel locations and functions, and gene-associated peptides.