## Abstract The cerebral deposition of amyloid Ξ²βpeptide, a central event in Alzheimer's disease (AD) pathogenesis, begins several years before the onset of clinical symptoms. Noninvasive detection of AD pathology at this initial stage would facilitate intervention and enhance treatment success. In
β¦ LIBER β¦
Neuropathological changes in the PDAPP transgenic mouse model of Alzheimers disease
β Scribed by Hamed Omidi; Parichehr Pasbakhsh; Kobra Mehrannia; Ali Gholi Sobhani
- Book ID
- 119379524
- Publisher
- Elsevier Science
- Year
- 2007
- Tongue
- English
- Weight
- 86 KB
- Volume
- 172
- Category
- Article
- ISSN
- 0378-4274
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Abnormal subgranular zone (SGZ) neurogenesis is proposed to contribute to Alzheimer's disease (AD)-related decreases in hippocampal function. Our goal was to examine hippocampal neurogenesis in the PDAPP mouse, a model of AD with age-dependent accumulation of amyloid-β€ 42 (Aβ€ 42 )-containing plaques
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