Neuropathologic findings in multi-infarct dementia associated with anticardiolipin antibody. Evidence for endothelial injury as the primary event
✍ Scribed by Eric M. Westerman; Janet M. Miles; Miroslav Backonja; Walter R. Sundstrom
- Book ID
- 102751912
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 848 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0004-3591
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✦ Synopsis
Abstract
Objective. There are few reports describing histopathologic changes associated with the antiphospholipid antibody syndrome. We describe a patient with multi‐infarct dementia and antiphospholipid antibody syndrome, in whom a brain biopsy was performed.
Methods. Biopsy material from the left frontal cortex, including meninges, cortex, and underlying subcortical white matter, was investigated. Microscopic examination and special staining were performed.
Results. Microscopic examination showed lumenal occlusion by thrombi, and marked endothelial hyperplasia of small meningeal and cortical arterioles.
Conclusion. These findings suggest that the pathogenesis of this cerebral vasculopathy is noninflammatory and is associated with reactive endothelial hyperplasia and thrombosis of small arterioles.