## Abstract Damage to the nervous system often results in neuropathic pain. Current treatment for this disabling state is unsuccessful due to our incomplete understanding of cellular mechanisms causing this pain. Although glial cells were largely ignored in most textbooks of pain, accumulating evid
Neuropathic pain and the electrophysiology and pharmacology of nerve injury
β Scribed by Peter A. Smith; Martin J. Stebbing; Timothy D. Moran; Pekka Tarkkila; Fuad A. Abdulla
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 171 KB
- Volume
- 54
- Category
- Article
- ISSN
- 0272-4391
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Neuropathic pain, a debilitating chronic pain following nerve damage, is a reflection of the aberrant functioning of a pathologically altered nervous system. One hallmark is abnormal pain hypersensitivity to innocuous stimuli (tactile allodynia), for which effective therapy is lacking, and the under
We have previously shown that activation of the ATP-gated ion channel subtype P2X 4 receptors (P2X 4 Rs) in the spinal cord, the expression of which is upregulated in microglia after nerve injury, is necessary for producing neuropathic pain. The upregulation of P2X 4 Rs in microglia is, therefore, a
## Abstract Despite the general capacity of peripheral nervous system to regenerate, peripheral nerve injury is often followed by incomplete recovery of function, sometimes with the burden of neuropathic pain. The mechanisms of both regeneration and nociception have not been clarified, but it is kn
## Abstract This review addresses the issue of how axotomy of peripheral nerve fibers leads to pain and hyperalgesia. The point of axotomy (the nerve injury site), the dorsal root ganglia, and the dorsal horn of the spinal cord are candidate sites for generation of the pain signal that is likely to