✦ LIBER ✦
Neurons from substantia nigra increase the efficacy and potency of second messenger arising from striatal astroglia dopamine receptor
✍ Scribed by Dr. Elisabeth Hansson; Lars Rönnbäck
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- English
- Weight
- 429 KB
- Volume
- 1
- Category
- Article
- ISSN
- 0894-1491
No coin nor oath required. For personal study only.
✦ Synopsis
Dopamine (D1) receptors were demonstrated to be present on astroglial cells from striatum in primary culture. In a cocultivation system, the astrocytes were influenced by neurons from one of their natural projection areas (substantia nigra) to increase the efficacy and potency of second messenger (cyclic AMP) from the dopamine receptor. This provides evidence for a heterogeneity among astroglia from the various brain regions with respect to the expression of receptors.