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Neuronal nicotinic acetylcholine receptor α4 subunit (CHRNA4) and panic disorder: An association study

✍ Scribed by Steinlein, Ortrud K.; Deckert, Jürgen; Nöthen, Markus M.; Franke, Petra; Maier, Wolfgang; Beckmann, Helmut; Propping, Peter

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
210 KB
Volume
74
Category
Article
ISSN
0148-7299

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✦ Synopsis

Anxiety disorders have been reported to be associated with low-voltage EEG (LVEEG).

Some cases with LVEEG (approximately 1 ⁄3) have been linked to chromosome 20q13.2-q13.3. In the same chromosomal region, the gene for the neuronal nicotinic acetylcholine receptor ␣4 subunit (CHRNA4) has been located. We therefore tested the hypothesis that polymorphisms in the CHRNA4 gene show an allelic association with panic disorder. We examined the allele frequencies of three different CHRNA4 polymorphisms in patients with panic disorder and in healthy controls. No significant differences in the allele frequencies of these three polymorphisms were noted. This study does not support an association between panic disorder and the CHRNA4 gene. Am.

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✍ Steinlein, Ortrud; Sander, Thomas; Stoodt, Jens; Kretz, Rebekka; Janz, Dieter; P 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 36 KB 👁 2 views

The ␣4 subunit gene of the neuronal nicotinic acetylcholine receptor (CHRNA4) has recently been identified as the first gene underlying an idiopathic partial epilepsy syndrome in human, autosomal-dominant nocturnal frontal lobe epilepsy (ADNFLE). CHRNA4 is located in the candidate region for benign