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Neuronal globus pallidus activity in patients with generalised dystonia

✍ Scribed by Marcelo Merello; Daniel Cerquetti; Angel Cammarota; Eduardo Tenca; Carlos Artes; Julio Antico; Ramon Leiguarda

Book ID
102945018
Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
533 KB
Volume
19
Category
Article
ISSN
0885-3185

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✦ Synopsis

Abstract

We studied 516 globus pallidus neurons in dystonic patients. The firing rate was analysed. We classified the burst activity into tonic, burst, and pause patterns. Mean Β± SD firing rates and tonicity score for internal globus pallidus (GPi) and external globus pallidus (GPe) were 54.6 Β± 28.6; 58.01 Β± 39.1 and 1.18 Β± 0.55; 0.95 Β± 0.43, respectively. Differences in percentage appearance of tonic, burst, or paused neurons were not statistically significant for GPi versus GPe. GPi firing features in dystonic patients were closely similar to those of GPe. This could suggest that the abnormally patterned output from GPi would not result from increased differential inhibitory/excitatory input arising from the direct/indirect pathway but rather be transmitted from GPe, striatum, or either centromedian nucleus. Β© 2003 Movement Disorder Society

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