Neuronal binding of tetanus toxin compared to its ganglioside binding fragment (Hc)

Immunization does not interfere with upt

Immunization does not interfere with uptake and transport by motor neurons of the binding fragment of tetanus toxin

✍ Paul S. Fishman; Christopher C. Matthews; Deborah A. Parks; Michael Box; Neil F. 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 99 KB

## Abstract The nontoxic binding domain of tetanus toxin (fragment C or TTC) readily undergoes retrograde axonal transport from an intramuscular injection site. This property has led to investigation of TTC as a possible vector for delivering therapeutic proteins to motor neurons. However, the vast