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Neuron-Specific Expression of Tomosyn1 in the Mouse Hippocampal Dentate Gyrus Impairs Spatial Learning and Memory

✍ Scribed by Boaz Barak, Eitan Okun, Yoav Ben-Simon, Ayal Lavi, Ronit Shapira…


Book ID
120897991
Publisher
Humana Press Inc
Year
2013
Tongue
English
Weight
884 KB
Volume
15
Category
Article
ISSN
1535-1084

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## Abstract Mutations in the __CLN6__ gene cause a variant form of late infantile neuronal ceroid lipofuscinosis, a relentless neurodegenerative disease that is inherited as an autosomal recessive trait in humans and in the naturally occurring __nclf__ mouse strain. The CLN6 protein is localized in