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Neuromelanin synthesis in rat and human substantia nigra

โœ Scribed by J. M. Rabey; F. Hefti


Publisher
Springer
Year
1990
Tongue
English
Weight
962 KB
Volume
2
Category
Article
ISSN
1435-1463

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## Abstract Levodopa (LD) is the most effective drug for symptomatic control of Parkinson's disease, but has been suspected to be toxic to substantia nigra (SN) dopaminergic neurons. Tissue culture and animal studies of LD toxicity have produced contradictory evidence, and one study reported that a