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Neurological and pharmacological evaluation of a case of stiff-man syndrome

✍ Scribed by A. Boiardi; P. Crenna; G. Bussone; S. Negri; B. Merati

Publisher
Springer
Year
1980
Tongue
English
Weight
334 KB
Volume
223
Category
Article
ISSN
0340-5354

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✦ Synopsis

A typical case of stiff-man syndrome was studied neurophysiologically and pharmacologically focusing the attention on a central disorder, either spinal or suprasegmental. The results support the hypothesis that a gamma type of hypertonia is one of the causes of the stiff-man syndrome, ruling out the participation of the Renshaw circuits. The syndrome should be considered a central disorder of the descending pathways that control and modify gamma activity and the startle reaction mechanisms, especially affecting the circuits that use Gabaergic mediators.

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