Neurologic complications of ovarian carcinoma

✍ Scribed by Lauren E. Abrey; Josep O. Dalmau

• Publisher: John Wiley and Sons
• Year: 1999
• Tongue: English
• Weight: 235 KB
• Volume: 85
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/(sici)1097-0142(19990101)85:1<127::aid-cncr18>3.0.co;2-7

✦ Synopsis

BACKGROUND.

Neurologic complications of ovarian carcinoma are uncommon and to the authors' knowledge the full spectrum has not been delineated previously.

METHODS.

The authors reviewed the findings of 121 neurologic consultations on 83 ovarian carcinoma patients between 1993 and 1996; this represents 4% of all ovarian carcinoma patients seen at the study institution in this time period.

RESULTS.

The most common reasons for consultation were altered mental status, pain, weakness, numbness, headache, and seizure. Twenty-seven consultations diagnosed metastatic disease, 14 diagnosed cerebrovascular disease, and 4 diagnosed paraneoplastic syndromes; however, iatrogenic complications (n ϭ 38) comprised the majority of diagnoses. Greater than 50% of patients improved neurologically after diagnosis and treatment.

CONCLUSIONS.

Neurologic disease accompanying ovarian carcinoma may be more common and more diverse than recognized previously. Definitive neurologic diagnosis and treatment benefits the majority of patients.