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Neuroleptic/dopamine receptors: search for new g-linked receptors

โœ Scribed by P. Seeman; H.B. Niznik; T. Nguyen; A. Tirpak; K.R. Jarvie; Y. Israel; B.F. O'Dowd


Book ID
115883691
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
227 KB
Volume
183
Category
Article
ISSN
0014-2999

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An interaction or link between dopamine D1 receptors and dopamine D2 receptors was found by a ligand competition method, using [3Hlraclopride to label dopamine D2 receptors and SCH 23390 to block dopamine D1 receptors. In the presence of endogenous or exogenous dopamine, SCH 23390 increased the bind