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Neuroleptic medications inhibit complex I of the electron transport chain

✍ Scribed by Vernice Jackson-Lewis; Serge Przedborski

Publisher: John Wiley and Sons
Year: 1994
Tongue: English
Weight: 246 KB
Volume: 35
Category: Article
ISSN: 0364-5134
DOI: 10.1002/ana.410350221

No coin nor oath required. For personal study only.

✦ Synopsis

Kano and associates [I) reported a patient with positive human T-lymphotrophic virus type I (HTLV-I) antibodies whose symptoms, similar to those of Shy-Drager syndrome, improved with corticosteroid therapy. They suggested that HTLV-I infection is related to Shy-Drager syndromelike neurological disorders. In fact, tremor has been reported in 27% and mild cerebellar ataxia in 5% of patients with usual HTLV-I-associated myelopathy (HAM), in addition to cardinal features of HAM; i.e., slowly progressive spastic paraparesis and mild sphincter and sensory disturbances 123.

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