Neuroleptic binding to sigma receptors: Possible involvement in neuroleptic-induced acute dystonia

Neuroleptics with differential affinitie

Neuroleptics with differential affinities at dopamine D2 receptors and sigma receptors affect differently the N-methyl-D-aspartate-induced increase in intracellular calcium concentration: Involvement of protein kinase

✍ Teruo Hayashi; Tsung-Ping Su; Ariyuki Kagaya; Akira Nishida; Masami Shimizu; Shi 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 130 KB 👁 2 views

This study examined the effect of chronic antipsychotic treatment on the NMDA-elicited changes in intracellular free Ca2+ concentration ([Ca2+]i) in the primary culture of rat frontal cortical neurons. Antipsychotics used in the study were chosen for their differential affinities at dopamine D2 rece