Neuroinflammatory and behavioural changes in the Atp7B mutant mouse model of Wilson’s disease
✍ Scribed by Dick Terwel; Yi-Na Löschmann; Hartmut H.-J. Schmidt; Hans R. Schöler; Tobias Cantz; Michael T. Heneka
- Book ID
- 111184492
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 469 KB
- Volume
- 118
- Category
- Article
- ISSN
- 0022-3042
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📜 SIMILAR VOLUMES
The gene ATP7B responsible for Wilson's disease (WD) produces a protein which is predicted to be a copper-binding P-type ATPase, homologous to the Menkes disease gene (ATP7A). Various mutations of ATP7B have been identified. This study aimed to detect disease-causing mutations, to clarify their freq
ATP7B is a copper transporting P-type ATPase defective in the autosomal recessive copper storage disorder, Wilson disease (WND). Functional assessment of variants helps to distinguish normal from disease-causing variants and provides information on important amino acid residues. A total of 11 missen