Neuroinflammation — From Bench to Bedside

✍ Scribed by H. Kettenmann (auth.), H. Kettenmann, G. A. Burton, U. J. Moenning (eds.)

• Publisher: Springer-Verlag Berlin Heidelberg
• Year: 2002
• Tongue: English
• Leaves: 245
• Series: Ernst Schering Research Foundation Workshop 39
• Edition: 1
• Category: Library

✦ Synopsis

Recent work has implicated inflammatory processes in the pathophysiology of a variety of neurodegenerative diseases such as Alzheimer's disease, stroke and multiple sclerosis. In this book leading experts in the field discuss molecular, in vivo and clinical aspects of neuroinflammation. It is hoped, with the wealth of research being conductied in this area, that novel therapeutic targets will be identified which will allow successful therapeutic intervention in a variety of neurodegenerative diseases.

✦ Table of Contents

Front Matter....Pages I-XIV
Cellular Components of Neuroinflammation — An Introduction....Pages 1-9
Microglia and the Response to Brain Injury....Pages 11-24
Elucidating Molecular Mechanisms of Alzheimer’s Disease in Microglial Cultures....Pages 25-44
Neuronal SLC (CCL21) Expression: Implications for the Neuron-Microglial Signaling System....Pages 45-60
Cytokine-Mediated Inflammation and Other Actions in the Central Nervous System....Pages 61-83
BSE, Scrapie, and vCJD: Infectious Neurodegenerative Diseases....Pages 85-103
Activated Microglia in Alzheimer’s Disease and Stroke....Pages 105-132
Inflammation in Stroke — A Potential Target for Neuroprotection?....Pages 133-157
Neuroinflammation in Alzheimer’s Disease: Potential Targets for Disease-Modifying Drugs....Pages 159-178
The Concept of In Vivo Imaging of Neuroinflammation with 11 C-PK11195 PET....Pages 179-191
Chemokine Receptors on Mononuclear Phagocytes in the Central Nervous System of Patients with Multiple Sclerosis....Pages 193-211
The Role of Apoptosis in Neuroinflammation....Pages 213-229
Back Matter....Pages 231-238

✦ Subjects

Neurology; Neurosciences