Neuroinflammation and Neurodegeneration

✍ Scribed by Phillip K. Peterson, Michal Toborek (eds.)

• Publisher: Springer-Verlag New York
• Year: 2014
• Tongue: English
• Leaves: 606
• Edition: 1
• Category: Library

✦ Synopsis

State of the art reviews by experts in the fields of neuroscience, immunology, microbiology/infectious diseases and pharmacology addressing the convergence of the immune system (neuroinflammation) and the loss of neurons (neurodegeneration). Many of the diseases that are discussed in the book are of epidemic proportion, e.g., Alzheimer’s disease, Parkinson’s disease, stroke, viral encephalitides and substance abuse. In addition to discussions of the involvement of neuroinflammation and neurodegeneration in these disorders, scientific reviews are presented on the cells and mediators that participate in defense of and damage to the nervous system. With rare exception, no or inadequate treatment exists for the diseases discussed in this book. An underlying premise of the book is that understanding of their shared pathogenic mechanisms will lead to improved therapies. Given the rapid evolution of the field of Neuroimmune Pharmacology, readers will find this book to be the most timely and authoritative reference on the subject of each of its chapters.

✦ Table of Contents

Front Matter....Pages i-xvii
Front Matter....Pages 1-1
The Blood-Brain Barrier....Pages 3-28
Immune Cell Trafficking in the Central Nervous System....Pages 29-45
General Physiology and Pathophysiology of Microglia....Pages 47-60
Inflammation and the Pathophysiology of Astrocytes in Neurodegenerative Diseases....Pages 61-80
Oxidative Stress, Neuroinflammation, and Neurodegeneration....Pages 81-104
Peripheral Neuroimmune Interactions and Neuropathic Pain....Pages 105-116
Front Matter....Pages 117-117
Innate and Adaptive Immune-Mediated Neuroinflammation and Neurodegeneration in Parkinson’s Disease....Pages 119-142
Multiple Sclerosis: Impact on Functioning of the Blood–Brain Barrier....Pages 143-160
Neuroinflammation in Alzheimer’s Disease....Pages 161-177
Neuroinflammation in Huntington’s Disease....Pages 179-197
Neuroinflammation and Immune Regulation in Ischemic Stroke: Identification of New Pharmacological Targets....Pages 199-244
Front Matter....Pages 245-245
HIV/NeuroAIDS....Pages 247-262
Herpes Simplex Virus Infections of the Central Nervous System....Pages 263-290
Congenital Cytomegalovirus Disease....Pages 291-308
Japanese Encephalitis: A Tale of Inflammation and Degeneration in the Central Nervous System....Pages 309-335
The Biology and Clinical Consequence of Infection with the Human Polyomavirus JCV....Pages 337-354
Role of Retrovirus-Induced Transactivator Proteins in Neuroinflammatory Disease....Pages 355-385
Immunopathogenesis of Bacterial Meningitis....Pages 387-404
Cerebral Malaria....Pages 405-428
Front Matter....Pages 429-429
HIV and Cocaine Interplay in HIV-Associated Neurocognitive Disorders....Pages 431-442
Front Matter....Pages 429-429
Methamphetamine Neurotoxicity and Neuroinflammatory Processes....Pages 443-462
Drugs of Abuse and NeuroAIDS: Opiates....Pages 463-486
Cannabinoids....Pages 487-510
Alcohol and Neurodegeneration....Pages 511-526
Front Matter....Pages 527-527
Cell-Based Drug Delivery for Improving Antiretroviral Therapeutic Outcomes....Pages 529-546
Immunomodulatory Therapeutics....Pages 547-567
Therapeutic Potential of Cannabinoids....Pages 569-587
Back Matter....Pages 589-600

✦ Subjects

Neurosciences; Neurochemistry; Neurobiology