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Neuroimaging studies of the hippocampus in schizophrenia

✍ Scribed by Stephan Heckers

Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
448 KB
Volume
11
Category
Article
ISSN
1050-9631

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✦ Synopsis

Abstract

Three neuroimaging techniques, morphometric neuroimaging, magnetic resonance spectroscopy, and functional neuroimaging, have provided evidence for abnormal hippocampal structure and function in schizophrenia. Hippocampal volume reduction is now one of the most consistent structural abnormalities found in schizophrenia: it is present at the onset of the illness and, to a lesser degree, in first‐degree relatives of schizophrenic probands. Decreased levels of N‐acetyl‐aspartate point towards a cellular basis of such volume changes. Functional neuroimaging studies have demonstrated abnormal levels of hippocampal activity at rest, during the experience of auditory hallucinations, and during the performance of memory retrieval tasks. These results of neuroimaging studies complement evidence from post‐mortem and behavioral studies, which have found regionally specific abnormalities of the hippocampus and of memory function in schizophrenia. Hippocampus 2001;11:520–528. Β© 2001 Wiley‐Liss, Inc.

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