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Neuroimaging and Proteomic Tracking of Neurodegeneration in MPTP-Treated Mice

✍ Scribed by HOWARD E. GENDELMAN; CHRISTOPHER J. DESTACHE; MARINA L. ZELIVYANSKAYA; JAY A. NELSON; MICHAEL D. BOSKA; TONI M. BISKUP; MICHAEL K. McCARTHY; KIMBERLY A. CARLSON; CRAIG NEMECHEK; ERIC J. BENNER; R. LEE MOSLEY


Book ID
111398323
Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
102 KB
Volume
991
Category
Article
ISSN
0890-6564

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We reported previously the protective effect of 17beta-estradiol (17beta-E(2)) on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopamine (DA) depletion. This protection was stereospecific, because 17beta-E(2) showed activity but 17alpha-estradiol (17alpha-E(2)) did not. The mechanisms