Neurohormonal activation in severe heart failure: Relations to patient death and the effect of treatment with flosequinan
โ Scribed by Gordon W. Moe; Jean L. Rouleau; Lynne Charbonneau; Guy Proulx; J.Malcolm O. Arnold; Christian Hall; Jacques de Champlain; Aiala Barr; Pierre Sirois; Milton Packer; Candian PROFILE investigators
- Book ID
- 117008553
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 889 KB
- Volume
- 139
- Category
- Article
- ISSN
- 1097-6744
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Angiotensin converting enzyme inhibitors have greatly improved the treatment of patients with chronic heart failure but they are not effective in all patients, and their use may be limited by side effects. There is, therefore, a need to investigate new drugs and to compare their efficacy with angiot
The acute central haemodynamic and neuroendocrine effects of intravenous flosequinan were studied in a group of 10 patients with severe heart failure. Flosequinan improved cardiac output by a maximum of 1.59 l.min-1, it reduced pulmonary capillary wedge pressure by 11.9 mm Hg and it also caused a re