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Neurogenesis decreases with age in the canine hippocampus and correlates with cognitive function

✍ Scribed by Christina T. Siwak-Tapp; Elizabeth Head; Bruce A. Muggenburg; Norton W. Milgram; Carl W. Cotman


Book ID
116791558
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
685 KB
Volume
88
Category
Article
ISSN
1074-7427

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The effects of aging on extracellular glutamate and tissue dynorphin content in the hippocampus were examined in Fischer-344 rats. Young adult (4-month-old) and aged (24-month-old) rats were trained to find a hidden platform in the Morris water task. Aged rats were unable to acquire the spatial lear