We study the neurogenesis of a distinct subclass of rat striatum β₯-aminobutyric acid (GABA)ergic interneurons marked by the calcium-binding protein parvalbumin (PV). Timed pregnant rats are given an intraperitoneal injection of bromodeoxyuridine (BrdU), a marker of cell proliferation, on designated
Neurogenesis and stereological morphometry of calretinin-immunoreactive GABAergic interneurons of the neostriatum
β Scribed by Vladimir V. Rymar; Rachel Sasseville; Kelvin C. Luk; Abbas F. Sadikot
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 719 KB
- Volume
- 469
- Category
- Article
- ISSN
- 0021-9967
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On the basis of cytochemical and morphologic differences, two classes of gamma-aminobutyric acidergic (GABAergic) interneurons expressing calcium-binding proteins have been identified in the striatum of adult animals: neurons expressing either parvalbumin (PV) or calretinin (CR). The function of the
## Abstract The marked atrophy of the striatum seen in Huntington's disease (HD) is largely due to a massive neuronal loss that affects the striatal projection neurons more severely than the local circuit neurons. We recently reported the existence of a new class of interneurons characterized by th