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Neurofibromin Negatively Regulates Neurotrophin Signaling through p21ras in Embryonic Sensory Neurons

✍ Scribed by Kristine S. Vogel; Mary El-Afandi; Luis F. Parada


Book ID
115637632
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
317 KB
Volume
15
Category
Article
ISSN
1044-7431

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## Abstract Neurotrophin‐3 (NT‐3) can negatively modulate trkA and associated phenotype in intact sensory neurons, while positively regulating trkC and associated phenotype. How NT‐3 effects this response is not clear. Whether NT‐3 exerts a differential influence on levels of activated ERK1/2 signa