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Neuroendocrine effects of ipsapirone on the hypothalamic-pituitary adrenal axis: CRF, ACTH and cortisol in healthy volunteers

✍ Scribed by M. Beneke; W. Wingender; R. Horstmann; I. Konrad-Dalhoff; H. Weber; J. Kuhlmann; B. H. Schmidt

Publisher: Springer
Year: 1992
Tongue: English
Weight: 540 KB
Volume: 42
Category: Article
ISSN: 0031-6970
DOI: 10.1007/bf00278478

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✦ Synopsis

The neuroendocrine effects (changes in plasma CRF, ACTH and cortisol) of single and multiple (t.d.s. for 2 days) doses of ipsapirone (BAY Q 7821) 5 and 10 mg have been investigated in 6 healthy male volunteers. The study followed a balanced complete block, placebo-controlled and double blind design with two baseline phases (pre and post-treatment). Volunteers were investigated on identical days during 5 successive weeks. The results do not show a specific effect of ipsapirone on the hypothalamic-pituitary-adrenal axis when doses in the range of 5-30 mg per day were given.

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