✦ LIBER ✦

Neuroendocrine differentiation in prostatic malignancy

✍ Scribed by P. Anthony di Sant'Agnese; Abraham T. K. Cockett

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 456 KB
Volume: 78
Category: Article
ISSN: 0008-543X
DOI: 10.1002/(sici)1097-0142(19960715)78:2<357::aid-cncr27>3.0.co;2-u

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✦ Synopsis

BACKGROUND.

The prostatic neuroendocrine cell is a regulatory cell that produces serotonin and peptide hormones. This cell is part of a more widely dispersed diffuse neuroendocrine regulatory system known as the APIJD system. Focal neuruendocrine differentiation is seen in virtually all prostate carcinomas to one degree or another. Specific malignancies that are purely neuroendocrine include small cell carcinoma and carcinoid/carcinoid-like tumors. A variety of studies suggest a possible prognostic significance of neuroendocrine differentiation in prostate carcinoma.

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