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Neurodegenerative parkinsonism and progressive external ophthalmoplegia with a Twinkle mutation

✍ Scribed by Wim Vandenberghe; Koen Van Laere; Frederik Debruyne; Christine Van Broeckhoven; Gert Van Goethem


Book ID
102504876
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
289 KB
Volume
24
Category
Article
ISSN
0885-3185

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✦ Synopsis


Parkinson's disease (PD) or other types of movement disorders occur worldwide in all ethnic groups and socioeconomic classes. 1,2 Because of the chronic and debilitating symptoms of PD or other types of movement disorders patients often use complementary medicine. [3][4][5] One such treatment option is qigong. Qigong is a form of traditional Asian medicine, which incorporates exercise for posture, coordination of different breathing patterns, movement, and meditation. It has been reported that qigong has beneficial effects in improving psychological health, reducing high blood pressure and pain, and modulating neurohormone and immune systems. 6-9 It, therefore, seems pertinent to evaluate the effectiveness of qigong for movement disorders. The objective of this systematic review is to summarize and critically assess the evidence of qigong for treating movement disorders.


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Digenic progressive external ophthalmopl
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Recently several mutations have been identified in nuclear genes that predispose to autosomal dominant or recessive progressive external ophthalmoplegia (PEO) with multiple deletions of mitochondrial DNA (mtDNA). In autosomal dominant PEO (adPEO, MIM# 157640), mutations were reported in the genes AN