Neurodegenerative overlap syndrome: Parkinsonism and motor neuron disorder

✍ Scribed by Akiko Imamura; Zbigniew Wszolek; Ryan Uitti

• Book ID: 102504804
• Publisher: John Wiley and Sons
• Year: 2007
• Tongue: English
• Weight: 44 KB
• Volume: 22
• Category: Article
• ISSN: 0885-3185
• DOI: 10.1002/mds.21183

✦ Synopsis

60% of patients with RBD, however, show neither a neurological sign nor a central nervous system lesion and may be considered to have idiopathic RBD. 5 The clinical symptoms of and PSG results concerning our patient support a diagnosis of idiopathic RBD.

Cardiac uptake of 123 I-MIBG, represented by the H/M ratio, in the present patient was reduced to the same extent as in IPD. Reduced myocardial 123 I-MIBG uptake may reflect the loss and/or dysfunction of cardiac postganglionic sympathetic nerve terminals. Our patient with RBD had reduced cardiac uptake of 123 I-MIBG characteristic of Lewy body disorders such as PD, DLB, and PAF. 3 Our patient's results suggest that postganglionic cardiac sympathetic nerve terminals are involved in some patients with idiopathic RBD. Such patients may have pathological features of Lewy body diseases and may develop PD or DLB within years or decades, as reported in the literature. 4 123 I-MIBG scintigraphy is a useful tool with which to clarify the pathological background of RBD, even at the early stage.