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Neurodegenerative disease: A new pathway to autophagy

โœ Scribed by Harrison, Charlotte


Book ID
109950574
Publisher
Nature Publishing Group
Year
2008
Tongue
English
Weight
425 KB
Volume
7
Category
Article
ISSN
1474-1776

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In the classical form of alpha1-antitrypsin (AT) deficiency, a point mutation in AT alters the folding of a liver-derived secretory glycoprotein and renders it aggregation-prone. In addition to decreased serum concentrations of AT, the disorder is characterized by accumulation of the mutant alpha1-a