Neurodegeneration in Multiple Sclerosis

✍ Scribed by E. Capello, A. Uccelli, M. Pizzorno, G.L. Mancardi (auth.), Massimo Filippi, Marco Rovaris, Giancarlo Comi (eds.)

Publisher: Springer-Verlag Mailand
Year: 2007
Tongue: English
Leaves: 233
Series: Topics in Neuroscience
Edition: 1
Category: Library

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✦ Synopsis

In multiple sclerosis (MS), conventional magnetic resonance imaging (cMRI) has proved to be a valuable tool to increase diagnostic reliability and to monitor the efficacy of experimental treatment. However, cMRI has limited specificity and accuracy as to the most disabling aspects of the MS pathology, known to occur in and outside macroscopic lesions. Modern quantitative MR techniques have the potential to overcome the limitations of cMRI, and their application is dramatically changing our understanding of how MS causes irreversible disability. Written by world-renowned scientists, the volume is indispensable for anybody working in this field.

✦ Table of Contents

Front Matter....Pages I-XI
Front Matter....Pages 1-1
Neuropathological Advances in Multiple Sclerosis....Pages 3-9
Neurophysiology....Pages 11-20
Front Matter....Pages 21-21
Atrophy....Pages 23-35
T1 Black Holes and Gray Matter Damage....Pages 37-45
Magnetization Transfer Imaging....Pages 47-53
Perfusion MR I....Pages 55-64
Diffusion-Weighted Imaging....Pages 65-74
Proton MR Spectroscopy....Pages 75-83
Functional MRI....Pages 85-104
Front Matter....Pages 105-105
Validation of MRI Surrogates....Pages 107-112
Defining Responders and Non-responders....Pages 113-125
Predictive Models in Multimodal Imaging....Pages 127-149
Front Matter....Pages 151-151
Alzheimer’s Disease....Pages 153-161
Other Neurodegenerative Conditions....Pages 163-181
Incorporation of Other Biomarkers....Pages 183-207
Front Matter....Pages 209-209
Critical Review of Existing Trials....Pages 211-220
Design for the Next Trials of Neurodegeneration....Pages 221-232
Back Matter....Pages 233-236

✦ Subjects

Neurology; Neurosciences; Imaging / Radiology; Neuroradiology; Nuclear Medicine

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