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Neurodegeneration in a Drosophila Model for the Function of TMCC2, an Amyloid Protein Precursor-Interacting and Apolipoprotein E-Binding Protein

✍ Scribed by Hopkins, Paul C. R.; Kretzschmar, Doris


Book ID
120256134
Publisher
Public Library of Science
Year
2013
Tongue
English
Weight
631 KB
Volume
8
Category
Article
ISSN
1932-6203

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## Abstract We have generated immortal neuronal cell lines from normal and trisomy 16 (Ts16) mice, a model for Down syndrome (DS). Ts16 lines overexpress DS‐related genes (__App__, amyloid precursor protein; __Sod1__, Cu/Zn superoxide dismutase) and show altered cholinergic function (reduced cholin