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Neurochemical Aspects of Excitotoxicity || Endogenous Antioxidant Mechanisms and Glutamate Neurotoxicity

✍ Scribed by Farooqui, Akhlaq A.

Book ID: 121417822
Publisher: Springer New York
Year: 2008
Tongue: English
Weight: 928 KB
Edition: 2008
Category: Article
ISBN: 0387730222
DOI: 10.1007/978-0-387-73023-3_9

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## Abstract Homocysteine (HC) is a neurotoxic amino acid that accumulates in several neurological disorders including Alzheimer's disease (AD). We examined the consequences of treatment of cultured murine cortical neurons with HC. Homocysteine‐induced increases in cytosolic calcium, reactive oxygen