The subventricular zone (SVZ) is distances along a highly stereotypical pathway. To the only germinal zone of the developing mammalian better understand the guidance cues used by SVZaforebrain to persist postnatally. Although the SVZ has derived cells during migration, both homotopic and been known to give rise to most of the glial cells of heterotopic transplantation experiments have been the forebrain, several studies over the past few years conducted. SVZa cells homotopically transplanted have shown that the cells of the neonatal and adult into another animal's SVZa migrate with the recipi-SVZ can also generate neurons. Recent studies have ent's endogenous SVZa cells in an indistinguishable demonstrated that a discrete region of the anterior manner, whereas those from the embryonic telencepart of the neonatal SVZ is composed exclusively of phalic ventricular zone, normally destined to follow neuronal progenitor cells, whose progeny become inradial glia to the cerebral cortex, fail to migrate folterneurons of the olfactory bulb. This review will exlowing transplantation to the SVZa. SVZa cells transplore the properties that distinguish this anterior segplanted heterotopically into the neonatal and adult ment of the neonatal subventricular zone (SVZa) striatum were able to disperse from their site of imfrom the more posterior, gliogenic region. The cells plantation. Thus, SVZa cells are special proliferating of the SVZa, as well as its anterior extension forming cells for which the rostral migratory stream is a parthe rostral migratory stream that enters the middle ticularly permissive pathway. แญง 1998 John Wiley & Sons, of the olfactory bulb, have antigenic characteristics of