Neuroblastoma Cell Death is Induced by Inorganic Arsenic Trioxide (As2O3) and Inhibited by a Normal Human Bone Marrow Cell-Derived Factor

Nitric oxide-induced programmed cell dea

Nitric oxide-induced programmed cell death in human neuroblastoma cells is accompanied by the synthesis of Egr-1, a zinc finger transcription factor

✍ Giuseppe Cibelli; Vincenza Policastro; Oliver G. Rössler; Gerald Thiel 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 218 KB 👁 1 views

## Abstract Nitric oxide (NO) is cytotoxic for human SH‐SY5Y neuroblastoma cells. While nuclear condensation was visible in cells treated with nitric oxide donors, we observed that the plasma membrane remained intact, indicating that NO induced apoptotic cell death. We analyzed the NO‐induced apopt