## Congenital central hypoventilation syndrome (CCHS; Ondine's Curse) is traditionally defined as the failure of automatic control of breathing. The term ''Ondine's curse'' was initially coined by Severinghaus and Mitchell in 1962 to describe a syndrome manifested in three adult patients after hi
Neuroanatomic deficits in congenital central hypoventilation syndrome
β Scribed by Rajesh Kumar; Paul M. Macey; Mary A. Woo; Jeffry R. Alger; Thomas G. Keens; Ronald M. Harper
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 779 KB
- Volume
- 487
- Category
- Article
- ISSN
- 0021-9967
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## Abstract Brain injury underlying the stateβrelated loss of ventilatory drive, autonomic, cognitive, and affective deficits in congenital central hypoventilation syndrome (CCHS) patients appears throughout the brain, as demonstrated by magnetic resonance (MR) T2 relaxometry and mean diffusivity s
## Abstract Congenital central hypoventilation syndrome (CCHS) is a rare syndrome characterized by failure of autonomic respiratory control, often presenting with other dysfunctions of the autonomic nervous system. Segregation analysis suggested a complex model of inheritance with a major locus inv
We report on a 2 1 β2-year-old boy who is currently ventilated at home by positive pressure ventilation through a nasal mask during the night because of congenital central hypoventilation syndrome (CCHS). Up to age 2 he had developed normally. A reevalution was performed because of symptoms suggesti
## Abstract ## Purpose To investigate whether mean diffusivity (MD) values are altered in brain areas underlying cardiovascular and respiratory control in congenital central hypoventilation syndrome (CCHS). ## Materials and Methods Conventional and diffusion tensor imaging were performed in 15 C