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Neuroactive steroids prevent peripheral myelin alterations induced by diabetes

✍ Scribed by Sergio Veiga; Emanuela Leonelli; Manolo Beelke; Luis M. Garcia-Segura; Roberto C. Melcangi


Book ID
116768657
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
143 KB
Volume
402
Category
Article
ISSN
0304-3940

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The regulation of phosphoinositidase C (PIC) activity by guanosine-5'-(3-O-thio)triphosphate (GTPyS) was characterized in a cholate-solubilized peripheral myelin-enriched fraction from rat sciatic nerve. The GTP analog maximally enhanced PIC-catalyzed hydrolysis of exogenous phosphatidylinositol-4,5