Neurite growth-inhibitory activity in the adult rat cerebral cortical gray matter
✍ Scribed by Ghosh, A. ;David, S.
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 249 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0022-3034
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✦ Synopsis
Axon growth-promoting and -inmembrane preparations is extractable with 3-[(3-chohibitory molecules are likely to work in concert to lamidoprophyl) -dimethylammonio] -1 -propane -sulpromote and guide axons in vivo. In adult mammals, fonate, but does not appear to be depleted by various inhibitory molecules associated with myelin in the lectins. Western blots and enzyme treatments showed white matter of the central nervous system (CNS) that the inhibitory effect of the gray-matter preparaplay an important role in the failure of long-distance tions is not likely to be mediated by myelin-associated axon regeneration. The presence of neurite growthinhibitors or chondroitin sulfate proteoglycans. Howinhibitory molecules in the adult rat gray matter has ever, tenascin was detected in these samples and may not been extensively studied. In this article we describe contribute to some of the inhibitory activity. Selective work on the characterization of neurite growth-inhibiseparation of the inhibitory molecules can be achieved tory activity in the adult rat cerebral cortical gray by ion-exchange chromatography, which also suggests matter using various biochemical and cell culture apthe presence of multiple inhibitors in cortical gray proaches. We show using a neuronal cell line (NG108matter membranes. ᭧ 1997 John Wiley & Sons, Inc. J 15 cells) that neurite growth-inhibitory activity is