Neurite growth and TPKI/GSK-3β-dependent phosphorylation of juvenile tau in cultured rat hippocampal neurons

Production of nerve growth factor by β-a

Production of nerve growth factor by β-amyloid-stimulated astrocytes induces p75NTR-dependent tau hyperphosphorylation in cultured hippocampal neurons

✍ Estefanía T. Sáez; Mariana Pehar; Marcelo R. Vargas; Luis Barbeito; Ricardo B. M 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 274 KB 👁 1 views

## Abstract Reactive astrocytes surround amyloid depositions and degenerating neurons in Alzheimer's disease (AD). It has been previously shown that β‐amyloid peptide induces inflammatory‐like responses in astrocytes, leading to neuronal pathology. Reactive astrocytes up‐regulate nerve growth facto