Neuregulin receptors erbB2 and erbB4 in failing human myocardium
β Scribed by S. Rohrbach; B. Niemann; R.-E. Silber; J. Holtz
- Publisher
- Springer
- Year
- 2005
- Tongue
- English
- Weight
- 323 KB
- Volume
- 100
- Category
- Article
- ISSN
- 0300-8428
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Neuregulins (NRGs) are a family of growth factors involved in signaling between neurons and glial cells of the peripheral and central nervous system. NRGs are synthesized and secreted by a number of cell types including Schwann cells, neurons, and oligodendrocytes. NRG transduction signals are media
## Abstract Neuregulins (NRG) belong to the EGF family of growth factors, which are ligands of the ErbB receptors. Their expression in the adult heart is essential, especially when the heart is submitted to cardiotoxic stress such as that produced by anthracyclines. It is considered that ErbB4 is t
## Abstract There is now strong evidence that Neuregulin 1 (NRG1) is a susceptibility gene for schizophrenia. NRG1 mediates some of its effects through the tyrosine kinase receptor erbB4, and analysis of gene knockβout animals suggests that the functional interaction of NRG1 and erbB4 mediates beha