Neuregulin and ErbB receptor signaling pathways in the nervous system
β Scribed by Andres Buonanno; Gerald D Fischbach
- Book ID
- 114313781
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 111 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0959-4388
No coin nor oath required. For personal study only.
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## Abstract Neuregulinβ1 (NRGβ1) proteins promote Schwann cell survival, differentiation and proliferation during development. High levels of an NRGβlike activity are also present in some human peripheral nerve sheath tumors, suggesting that NRGβ1 isoforms may be involved in the development of thes
## Abstract Neuregulins (NRG) belong to the EGF family of growth factors, which are ligands of the ErbB receptors. Their expression in the adult heart is essential, especially when the heart is submitted to cardiotoxic stress such as that produced by anthracyclines. It is considered that ErbB4 is t