Neurally-mediated vasodilatation in normal and portal hypertensive rats: role of nitric oxide and calcitonin gene-related peptide
β Scribed by Christine Moll-Kaufmann; Lazar T. Sumanovski; Cornel C. Sieber
- Book ID
- 118568123
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 101 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0168-8278
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Systemic and especially splanchnic arterial vasodilation accompany chronic portal hypertension. Different soluble mediators causing this vasodilation have been proposed, the strongest evidence being for nitric oxide (NO). No data exist if structural vascular changes may partly account for this vasod
This study investigated the effect of vasopressin on portal-systemic collaterals in portal hypertensive rats and the influence of nitric oxide (NO) and prostaglandin on the responsiveness of collateral vessels to vasopressin. The vascular responsiveness to graded concentrations of vasopressin was te