Neural tube defects and elevated homocysteine levels in amniotic fluid
✍ Scribed by Régine P. Steegers-Theunissen; Godfried H. Boers; Henk J. Blom; Jan G. Nijhuis; Chris M.G. Thomas; George F. Borm; Tom K. Eskes
- Book ID
- 115684938
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 532 KB
- Volume
- 172
- Category
- Article
- ISSN
- 1097-6868
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A specific gene mutation leading to altered homocysteine metabolism has been identified in parents and fetuses with neural tube defects (NTDs). In addition, current animal and human data indicate that spine closure occurs simultaneously in five separate sites that then fuse. We sought to determine w
A mutation in the gene 5,10-methylenetetrahydrofolate reductase (MTHFR), leading to altered homocysteine metabolism, has been identified in parents and fetuses with fetal neural tube defects. We sought to determine which is of greater importance in fetal neural tube defect formation: the fetal MTHFR