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Neural tissue engineering of the CNS using hydrogels

✍ Scribed by David R. Nisbet; Kylie E. Crompton; Malcolm K. Horne; David I. Finkelstein; John S. Forsythe

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
342 KB
Volume
87B
Category
Article
ISSN
1552-4973

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Current therapies have limited capacity to curtail disease progression or damage of the central nervous system (CNS) of adult mammals and successful regeneration following injury or disease does not occur. Regeneration of the CNS is limited by physical and chemical inhibitory barriers within the injured environment and the absence of positive cues that elicit and guide repair. Neural tissue engineering strategies focus on developing scaffolds that artificially generate favourable cellular microenvironments that attempt to tip the balance in favour of regeneration. Some recent advances using scaffolds to promote regeneration within the CNS, particularly in conjunction with stem cells, has generated promising results. This review focuses on hydrogel scaffolds which have been used extensively in neural tissue engineering applications and addresses the physical and chemical modifications of these materials to promote nerve regeneration. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2008

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