𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Neural stem cells in the developing and adult brains

✍ Scribed by Qiuhao Qu; Yanhong Shi

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
153 KB
Volume
221
Category
Article
ISSN
0021-9541

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Neural stem cells exist in the mammalian developing and adult nervous system. Recently, tremendous interest in the potential of neural stem cells for the treatment of neurodegenerative diseases and brain injuries has substantially promoted research on neural stem cell self‐renewal and differentiation. Multiple cell‐intrinsic regulators coordinate with the microenvironment through various signaling pathways to regulate neural stem cell maintenance, self‐renewal, and fate determination. This review focuses on essential intracellular regulators that control neural stem cell maintenance and self‐renewal in both embryonic brains and adult nervous system. These factors include the orphan nuclear receptor TLX, the high‐mobility‐group DNA binding protein Sox2, the basic helix‐loop‐helix transcription factor Hes, the tumor suppressor gene Pten, the membrane‐associated protein Numb, and its cytoplasmic homolog Numblike. The aim of this review is to summarize our current understanding of neural stem cell regulation through these important stem cell regulators. J. Cell. Physiol. 221: 5–9, 2009. © 2009 Wiley‐Liss, Inc

📜 SIMILAR VOLUMES

PACAP promotes neural stem cell prolifer
PACAP promotes neural stem cell proliferation in adult mouse brain
✍ Alex Mercer; Harriet Rönnholm; Johan Holmberg; Hanna Lundh; Jessica Heidrich; Ol 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 324 KB

## Abstract In recent years, it has become evident that neural stem cells in the adult mammalian brain continuously generate new neurons, mainly in the hippocampus and olfactory bulb. Although different growth factors have been shown to stimulate neurogenesis in the adult brain, very little is know

Locating and labeling neural stem cells
Locating and labeling neural stem cells in the brain
✍ Henrik Landgren; Maurice A. Curtis 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 149 KB 👁 1 views

## Abstract The phenomenon of adult neurogenesis has been demonstrated in most mammals including humans. At least two regions of the adult brain maintain stem cells throughout life; the subgranular zone (SGZ) of the hippocampal dentate gyrus, and the subventricular zone (SVZ) of the lateral ventric

Activation of endogenous neural stem cel
Activation of endogenous neural stem cells in the adult human brain following subarachnoid hemorrhage
✍ D. Sgubin; E. Aztiria; A. Perin; P. Longatti; G. Leanza 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 216 KB

## Abstract In the adult human brain, the presence of neural stem cells has been documented in the subgranular layer of the dentate gyrus of the hippocampus and in the subventricular zone of the lateral ventricles. Neurogenesis has also been reported in rodent models of ischemic stroke, traumatic b

Biology of the adult enteric neural stem
Biology of the adult enteric neural stem cell
✍ Sandino Estrada-Mondaca; Alfonso Carreón-Rodríguez; Jaime Belkind-Gerson 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 210 KB 👁 1 views

## Abstract An increasing body of evidence has accumulated in recent years supporting the existence of neural stem cells in the adult gut. There are at least three groups that have obtained them using different methodologies and have described them in vitro. There is a growing amount of knowledge o