Neural Plasticity and Regeneration

✍ Scribed by F.J. Seil (Eds.)

• Publisher: Elsevier Science B.V
• Year: 2000
• Tongue: English
• Leaves: 353
• Series: Progress in brain research 128
• Edition: 1st ed
• Category: Library

✦ Synopsis

While a cure for spinal cord injury remains elusive, the contents of this volume convey a sense of progress towards this goal. More has been learned about the primary and secondary consequences of spinal cord injury and more is being understood about recovery mechanisms that are intrinsic to the nervous system and that might be further encouraged. Expanding the control capacity of uninjured portions of the nervous system may be one approach to improving the functional capabilities of those afflicted with this disorder. New therapies in the form of transplantable cells that can encourage growth or myelination or prevent secondary damage or that can substitute for injured cells appear promising for future applications. Genetic and tissue engineering studies give us further hope, and under continuous development are novel drugs with greater specificity and fewer detrimental effects and improved delivery methods for such drugs. The volume is organized into six topic sections, including I) Strategies for Spinal Cord Injury Repair, II) Plasticity of the Injured Spinal Cord: Retraining Neural Circuits to Promote Motor Recovery, III) Impact of Neuroprosthetic Applications on Functional Recovery, IV) Neurotrophins and Activity-Dependent Plasticity, V) Candidate Cells for Transplantation into the Injured CNS and VI) New Directions in Regeneration Research. Both clinical and experimental animal studies are presented in the first three sections, while predominantly basic research is the focus of the second half of the book.

✦ Table of Contents

Content:
List of contributors
Pages v-viii

Preface
Pages ix-x
Fredrick J. Seil

Strategies for spinal cord injury repair Original Research Article
Pages 3-8
Dana M. McTigue, Phillip G. Popovich, Lyn B. Jakeman, Bradford T. Stokes

Cell death and plasticity after experimental spinal cord injury Original Research Article
Pages 9-21
Michael S. Beattie, Qun Li, Jacqueline C. Bresnahan

The multi-domain structure of extracellular matrix molecules: Implications for nervous system regeneration Original Research Article
Pages 23-31
Sally Meiners, Mary Lynn T. Mercado, Herbert M. Geller

Spinal cord injury-induced inflammation: A dual-edged sword Original Research Article
Pages 33-42
John R. Bethea

Immunological regulation of neuronal degeneration and regeneration in the injured spinal cord Original Research Article
Pages 43-58
Phillip G. Popovich

Plasticity of neuronal networks in the spinal cord: Modifications in response to altered sensory input Original Research Article
Pages 61-70
Keir G. Pearson

Neural plasticity as revealed by the natural progression of movement expression — Both voluntary and involuntary — In humans after spinal cord injury Original Research Article
Pages 71-88
Blair Calancie, Maria Del Rosario Molano, James G. Broton

Laufband (LB) therapy in spinal cord lesioned persons Original Research Article
Pages 89-97
Anton Wernig, Andreas Nanassy, Sabina Müller

Spinal and supraspinal plasticity after incomplete spinal cord injury: Correlations between functional magnetic resonance imaging and engaged locomotor networks Original Research Article
Pages 99-111
Bruce H. Dobkin

Impact of neuroprosthetic applications on functional recovery Original Research Article
Pages 115-120
John K. Chapin

Nerve cuffs for nerve repair and regeneration Original Research Article
Pages 121-134
Joaquín Andrés Hoffer, Klaus Kallesøe

Cortical motor areas and their properties: Implications for neuroprosthetics Original Research Article
Pages 135-160
Paul Dcheney, Jennifer Hill-Karrer, Abderraouf Belhaj-Saïf, Brian J. McKiernan, Michael C. Park, Joanne K. Marcario

Network level properties of short-term plasticity in the somatosensory system Original Research Article
Pages 161-172
David J. Krupa, Miguel A.L. Nicolelis

The reorganization of somatosensory and motor cortex after peripheral nerve or spinal cord injury in primates Original Research Article
Pages 173-179
Jon H. Kaas

Neurotrophins and activity-dependent plasticity Original Research Article
Pages 183-191
Hans Thoenen

Differences in the regulation of neuropeptide Y, somatostatin and parvalburnin levels in hippocampal interneurons by neuronal activity and BDNF Original Research Article
Pages 193-202
Serge Marty

Long-term regulation of excitatory and inhibitory synaptic transmission in hippocampal cultures by brain-derived neurotrophic factor Original Research Article
Pages 203-218
M. McLean Bolto, Donald C. Lo, Nina T. Sherwood

Neurotrophins and activity-dependent inhibitory synaptogenesis Original Research Article
Pages 219-229
Fredrick J. Seil, Rosemarie Drake-Baumann

Modulation of hippocampal synaptic transmission and plasticity by neurotrophins Original Research Article
Pages 231-241
Bai Lu, Wolfram Gottschalk

Neurotrophin-evoked rapid excitation of central neurons Original Research Article
Pages 243-249
Karl W. Kafitz, Christine R. Rose, Arthur Konnerth

Candidate cells for transplantation into the injured CNS Original Research Article
Pages 253-257
Itzhak Fischer

Autoimmune involvement in CNS trauma is beneficial if well controlled Original Research Article
Pages 259-263
Michal Schwartz

Olfactory ensheathing glia transplantation into the injured spinal cord Original Research Article
Pages 265-272
Almudena Ramón-Cueto

Precursor cells for transplantation Original Research Article
Pages 273-292
Mahendra S. Rao, Margot Mayer-Proschel

Potential use of marrow stromal cells as therapeutic vectors for diseases of the central nervous system Original Research Article
Pages 293-297
Darwin J. Prockop, S. Ausim Azizi, Donald G. Phinney, Gene C. Kopen, Emily J. Schwarz

Neurobiology of human neurons (NT2N) grafted into mouse spinal cord: Implications for improving therapy of spinal cord injury Original Research Article
Pages 299-307
Virginia M.-Y. Lee, Rebecca S. Hartley, John Q. Trojanowski

Grafting of genetically modified fibroblasts into the injured spinal cord Original Research Article
Pages 309-319
Yi Liu, Marion Murray, Alan Tessler, Itzhak Fischer

Delivery of therapeutic molecules into the CNS Original Research Article
Pages 323-332
Marina E. Emborg, Jeffrey H. Kordower

Neurotrophin small-molecule mimetics Original Research Article
Pages 333-347
Youmei Me, Frank M. Longo

Tissue engineering strategies for nervous system repair Original Research Article
Pages 349-363
Patrick A. Tresco

In vivo neuroprotection of injured CNS neurons by a single injection of a DNA plasmid encoding the Bcl-2 gene Original Research Article
Pages 365-372
Raul A. Saavedra, Marion Murray, Sonsoles de Lacalle, Alan Tessler

Subject index
Pages 373-375