Neural mitochondrial Ca2+ capacity impairment precedes the onset of motor symptoms in G93A Cu/Zn-superoxide dismutase mutant mice

Caloric restriction transiently improves

Caloric restriction transiently improves motor performance but hastens clinical onset of disease in the Cu/Zn-superoxide dismutase mutant G93A mouse

✍ Mazen J. Hamadeh; M. Christine Rodriguez; Jan J. Kaczor; Mark A. Tarnopolsky 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 118 KB

## Abstract Caloric restriction (CR) prolongs lifespan in insects, rodents, and nonhuman primates, a process attributed to a reduction in oxidative stress. Transgenic mice that overexpress the mutant human Cu/Zn‐superoxide dismutase (__SOD1__) gene (G93A mice) are an animal model of amyotrophic lat