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Neural control of the lower urinary tract: Peripheral and spinal mechanisms

✍ Scribed by L. Birder; W. de Groat; I. Mills; J. Morrison; K. Thor; M. Drake

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
290 KB
Volume
29
Category
Article
ISSN
0733-2467

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✦ Synopsis

Abstract

This review deals with individual components regulating the neural control of the urinary bladder. This article will focus on factors and processes involved in the two modes of operation of the bladder: storage and elimination. Topics included in this review include: (1) The urothelium and its roles in sensor and transducer functions including interactions with other cell types within the bladder wall (β€œsensory web”), (2) The location and properties of bladder afferents including factors involved in regulating afferent sensitization, (3) The neural control of the pelvic floor muscle and pharmacology of urethral and anal sphincters (focusing on monoamine pathways), (4) Efferent pathways to the urinary bladder, and (5) Abnormalities in bladder function including mechanisms underlying comorbid disorders associated with bladder pain syndrome and incontinence. Neurourol. Urodynam. 29: 128–139, 2010. Β© 2009 Wiley‐Liss, Inc.

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