✦ LIBER ✦

Neural cell adhesion molecule L1: relating disease to function

✍ Scribed by Sue Kenwrick; Patrick Doherty

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 128 KB
Volume: 20
Category: Article
ISSN: 0265-9247
DOI: 10.1002/(sici)1521-1878(199808)20:8<668::aid-bies10>3.0.co;2-x

No coin nor oath required. For personal study only.

✦ Synopsis

Neural cell adhesion molecules of the immunoglobulin superfamily are important components of the network of guidance cues and receptors that govern axon growth and guidance during development. For neural cell adhesion molecule L1, the combined application of human genetics, knockout mouse technology, and cell biology is providing fundamental insight into the role of L1 in mediating neuronal differentiation. Disease-causing mutations as well as mouse models of L1 disruption can now be used to examine the relevance of L1 binding specificities and signal transduction pathways that have been observed in vitro.

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