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Neuere Erkenntnisse zur Regulation des Sekundärstoffwechsels von Streptomyceten

✍ Scribed by U. Gräfe

Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
1005 KB
Volume
9
Category
Article
ISSN
0138-4988

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✦ Synopsis

A survey is given summarizing recent insights into the causes of the genetic segregation of antibiotic-producing Streptomyces strains (plasmids, transposons, reiterated gene sequences, direct and inverted repeats). Referring to the classical regulatory models of prokaryotic operons, similar regulatory principles were shown to be involved in the secondary metabolism (pab-gene of S. grisew, brp-gene of S. hygroseopicus, afs B-gene and A-factor of S. griseu.9) and the known features of its control by catabolites as well. The heterogeneity of the transcriptional system (multiple promotors and holoenzymes of the RNA polymerase) is shown to constitute an essential element of the secondary metabolism accomplishing its integration into cellular cytodifferentiation.

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